IGM Biosciences
Dr. Hambleton also serves on the Board of Directors at Accent Therapeutics, SpringWorks Therapeutics, and she previously served on the Board of Directors of Arch Oncology where she was also Interim Chief Executive Officer. Previously, she was the Chief Medical Officer and Head of Development at IDEAYA Biosciences, an oncology medicine company. Prior to IDEAYA, she was Vice President and Head of U.S. Medical at Bristol-Myers Squibb. She has also served as Executive Vice President and Chief Medical Officer at Five Prime Therapeutics, Vice President of Clinical Development at Clovis Oncology, and held increasing roles of responsibility in BioOncology at Roche/Genentech, most recently as Global Cluster Head and Global Group Medical Director. Dr. Hambleton completed her hematology-oncology training at the University of California, San Francisco, and served on the faculty there from 1993 to 2003. Dr. Hambleton received a B.S. in Nursing from Duke University and an M.D. from Case Western Reserve University School of Medicine. She is board-certified in Hematology and Internal Medicine.
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IGM Biosciences
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IGM Biosciences (Nasdaq: IGMS) is a clinical-stage biotechnology company focused on creating and developing engineered IgM antibodies. IgM antibodies have inherent properties that we believe may enable them to improve upon the efficacy and safety of IgG antibodies in multiple therapeutic applications. We have created a proprietary IgM antibody technology platform that we believe is particularly well suited for developing T cell engagers, receptor cross-linking agonists, and targeted cytokines. Our lead product candidate, IGM-2323, is a bispecific T cell engaging IgM antibody targeting CD20 and CD3, and we have initiated a Phase 1 clinical trial for the treatment of relapsed/refractory B cell Non-Hodgkin's lymphoma (NHL) patients in 2019. Our second product candidate is IGM-8444, an IgM antibody targeting Death Receptor 5 (DR5) for the treatment of patients with solid and hematologic malignancies, for which we have recently initiated a Phase 1 clinical trial. Also in our product pipeline is IGM-7354, a bispecific IgM antibody delivering interleukin-15 (IL-15) cytokines to PD-L1 expressing cells for the treatment of patients with solid and hematologic malignancies.