Director, Discovery Pharmacology

Position Summary:

MBX Biosciences is looking for a highly motivated and experienced Pharmacologist to join our drug discovery team as the Director of Discovery Pharmacology.  The successful individual will be responsible for overseeing the design, execution, and interpretation of pharmacology studies supporting the identification/assessment and validation of novel peptide-based therapeutics, and drug targets.  The discovery pharmacology leader will work collaboratively with cross functional teams (in vitro pharmacology, toxicology, medical, regulatory, academia and CROs) to ensure the timely delivery of high-quality data and reports.

Key Responsibilities:

• Provide strategic direction and scientific leadership for the discovery pharmacology, ensuring alignment with the company’s vision and goals.
• Strong interaction with VP Discovery, and with Discovery peptide and analytical chemists in support of building the MBX portfolio
• Recruit additional pharmacology staff, as required.
• Design and implement in vivo pharmacology studies to evaluate the efficacy, pharmacokinetics, pharmacodynamics, and safety of drug candidates.
• Interpret and communicate pharmacology data and results to internal and external stakeholders, including senior management, program teams, regulatory agencies, and scientific publications.
• Establish and maintain productive relationships with external collaborators, CROs, and academic institutions.
• Stay current in the latest scientific and technological advances in the field of peptide pharmacology and drug discovery.
• Contribute to the identification and validation of novel peptide targets, and therapeutic areas of interest.

• Interface, as necessary, with MBX Regulatory on submission of data to Regulatory Agencies.
• Provide input on discovery pharmacology strategic and tactical direction for multiple project teams as they advance novel peptides from target discovery through lead optimization to clinical development.
• Write or review pharmacology sections of Candidate Selection documents, and, as necessary, contribute to IND, Investigator Brochures (IB), NDA, and Biologics License Application (BLA).

Qualifications:

• PhD in Pharmacology, Biology, or related discipline, with minimum six (6) years of relevant experience in drug discovery and development. 

• Proven track record of working with cross functional  teams and projects in the areas of novel peptide target validation and development
• Knowledge and hands-on experience in various pharmacology techniques and models, including animal disease models, biomarkers, PK/PD, and toxicology.
• Excellent communication, presentation, and interpersonal skills, with the ability to work effectively in a matrixed and collaborative environment.
• Demonstrated ability to think creatively and strategically, and to solve complex scientific problems.
• Experience in working with external partners and CROs, and managing contracts and budgets.
• Familiarity with the drug development process and regulatory requirements
• Experience in working with external collaborators, CROs and Academic partners.

• Strong interpersonal skills and ability to represent Nonclinical Discovery pharmacology in cross functional teams.

• Ability to think strategically and to provide clear direction and expectations to other team members in a highly dynamic environment.
• Strong ability to prioritize daily work based on changing business requirements.
• Self-motivated, independent, and results oriented.

Company Overview:

MBX is an early clinical-stage biotech company pioneering a new era for peptide therapeutics to simplify management of endocrine diseases and enable greater access for patients.  MBX’s leadership team has collaborated successfully over several decades to discover, develop, and commercialize first-in-class therapeutics.

Our team is driven to transform the current treatment landscape with life-restoring therapies that offer precision pharmacology while reducing the frequency of injections or eliminating injections entirely. A distinguishing strength of MBX is world-class proprietary peptide drug discovery and platform technology. MBX is funded by leading venture capital firms including Frazier Healthcare Partners, OrbiMed, and New Enterprise Associates.

EEO Statement:

MBX Biosciences is an Equal Opportunity Employer and is committed to treating all applicants fairly without discrimination. We welcome applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.