NBE Therapeutics
Prof. Thomas Winkler is an Associate Professor for Genetics at the Nikolaus-Fiebinger Centre for Molecular Medicine of the University of Erlangen-Nuremberg, Germany, where his research focuses on understanding the genetic mechanisms for the early B-cell development and how defects in this may lead to loss of self-tolerance and the development of autoimmunity. In addition, his laboratory has a strong interest in understanding antibody- and B-lineage cell-mediated protection against viral infections using cytomegalovirus as a model system in mice and in translational approaches for the benefit of patients.
Prof. Winkler studied Biology at the University of Erlangen and did his Ph.D. work in the laboratory of Prof. Jochen Kalden, a world-renowned rheumatologist and autoimmune Immunologist. After that he did post-doctoral work on B cell Immunology at the Basel Institute for Immunology, a triple Nobel Prize awarded Swiss academic Institute. Following his post-doctoral research, he became a principal investigator at the Division of Molecular Medicine, at the University of Erlangen-Nuremberg, where in 2001 he was appointed Associate Professor for Genetics.
This person is not in the org chart
This person is not in any offices
NBE Therapeutics
1 followers
NBE-Therapeutics is developing best-in-class cancer therapies to increase survival and improve quality of life for cancer patients worldwide. The company’s next-generation immune-stimulatory therapies are based on a proprietary, highly differentiated Antibody-Drug Conjugate (ADC) platform. This best-in-class ADC platform creates highly potent and safe immune-stimulatory ADCs ("iADCs™") with an anthracycline payload, not only directly targeting tumor cells, but also inducing a long-lasting immunological anti-tumor effect. The company’s lead asset, NBE-002, an anti-ROR1 ADC, is due to start first-in-human clinical trials in three US centers by the end of 2020, focusing on triple negative breast cancer, but also other solid cancer indications which express ROR1. NBE-Therapeutics is a privately owned biotech company based in Basel, financed by Germany’s Boehringer Ingelheim Venture Fund, the Czech Republic’s PPF Group and Denmark’s Novo Holdings as international institutional investors, and by Swiss, German, and Dutch private investors. The company has raised over USD 65m, including a USD 22m Series C (2020), two USD 20m Series B rounds (2016 & 2018), a USD 3m Series A (2015), and over USD 4m from several non-dilutive grants from organizations including the Swiss Commission for Technology & Innovation, the European Commission, and Systems-X.