Prime Medicine
Ben Kleinstiver is a biochemist and genome editor whose research lab works at the intersection of protein engineering and the development of genetic engineering technologies. He received his Ph.D in Biochemistry from the University of Western Ontario, where he studied homing endonucleases and their application as monomeric nuclease technologies. He then completed his postdoctoral studies at Massachusetts General Hospital (MGH) and Harvard Medical School, focused on developing improved CRISPR-Cas enzymes. The Kleinstiver laboratory is situated within the Center for Genomic Medicine at MGH and is focused on accelerating the development of CRISPR technologies as genetic medicines. The major research goals in Dr. Kleinstiver’s laboratory are to overcome the limitations of naturally occurring enzymes to design more optimal technologies, to develop new capabilities that solve outstanding needs in the genome editing field, with the hope of transforming these technologies into safe and effective genetic therapies for patients.
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Prime Medicine
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Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA. A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations. We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients. Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.