Prime Medicine
Jim Haber received his AB from Harvard College and his PhD in Biochemistry at the University of California, Berkeley. After postdoctoral work at the University of Wisconsin, Madison, he joined the Department of Biology at Brandeis in 1972. He has been a leading researcher in the fields of DNA repair and DNA damage checkpoints for over forty years. By using inducible site-specific DNA cleavage, his lab has been able to monitor in real time the kinetics of DNA repair processes. They have identified many of the components and molecular intermediates in both nonhomologous end-joining and in several pathways of homologous recombination. In 2011 he received the Genetics Society of America’s Thomas Hunt Morgan Medal for Lifetime Achievement in Genetics. He is a member of the National Academy of Sciences, a Fellow of the American Academy of Microbiology, a Fellow of the American Association for the Advancement of Science and of the American Academy of Arts and Sciences.
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Prime Medicine
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Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA. A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations. We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients. Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.