Senior Associate Scientist/ Scientist I, Upstream Process Development

Scholar Rock is a biopharmaceutical company that discovers, develops, and delivers life-changing therapies for people with serious diseases that have high unmet need. As a global leader in the biology of the transforming growth factor beta (TGFβ) superfamily of cell proteins and named for the visual resemblance of a scholar rock to protein structures, the clinical-stage company is focused on advancing innovative treatments where protein growth factors are fundamental. Over the past decade, the company has created a pipeline with the potential to advance the standard of care for neuromuscular disease, cardiometabolic disorders, cancer, and other conditions where growth factor-targeted drugs can play a transformational role.   Scholar Rock is the only company to show clinical proof of concept for a muscle-targeted treatment in spinal muscular atrophy (SMA). This commitment to unlocking fundamentally different therapeutic approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. By harnessing cutting-edge science in disease spaces that are historically under-addressed through traditional therapies, Scholar Rock works every day to create new possibilities for patients. Learn more about the company’s approach at ScholarRock.com and follow @ScholarRock and on LinkedIn.

Summary of Position:

The Technical Operations Department at Scholar Rock is seeking a scientifically curious and motivated scientist in the Upstream Process Development group. The successful candidate will be responsible for developing and optimizing cell culture processes for antibody production and be comfortable working with a multifunctional team. Experience with mammalian cell culture techniques (ideally CHO cells) and bioreactor operation is preferred. The selected candidate will work alongside in-house scientists to advance existing projects through the development lifecycle and help start up new projects.

Position Responsibilities:

• Perform early and late-stage upstream process development for Scholar Rock’s products including cell line, bioreactor, and media development work
• Ability to thoroughly review manufacturing documents and troubleshoot outsourced manufacturing processes
• Support research, downstream process development, and assay development as needed

Candidate Requirements:

• Educational background in Chemical Engineering, Biochemistry, Biotechnology, or related biological Sciences
• Direct experience working with mAbs is preferred
• BS or MS with 2 – 5+ years of experience
• Experience with mammalian cell culture techniques
• Experience with tech transfer to manufacturing preferred
• Strong attention to detail required
• Some travel required