Prime Medicine
Andrew Anzalone joined Prime Medicine in 2020 as the head of the prime editing platform, where he currently leads efforts to advance technological developments in prime editing for human therapeutic applications.
Dr. Anzalone received his Sc.B. degree in chemistry from Brown University, where he performed undergraduate research in synthetic organic chemistry. He completed his M.D. and Ph.D. degrees at Columbia University as part of the Medical Scientist Training Program. Dr. Anzalone’s thesis research in Virginia W. Cornish’s laboratory focused on the design and synthesis of fluorescent probes for biological imaging applications, and on the investigation and engineering of RNA-dependent protein translation reprogramming mechanisms in eukaryotes. After completing his graduate studies, Dr. Anzalone pursued postdoctoral research as a Jane Coffin Childs Memorial Fund Postdoctoral Fellow in the laboratory of David R. Liu at the Broad Institute of Harvard and MIT. In the Liu laboratory, Dr. Anzalone pioneered the development of prime editing, a novel search-and-replace gene editing technology that has the potential to correct the majority of known human genetic variants associated with disease.
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Prime Medicine
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Prime Medicine was founded to bring the promise of gene editing to patients. We use Prime Editing, a next-generation technology that can “search and replace” to restore normal genetic function almost anywhere in the genome. Prime Editing searches to find the precise place in the genome to edit and replaces the segment of faulty DNA with a correct copy of DNA. A single Prime Editor can correct the individual mutations found across patients, meaning Prime Editing can potentially address more than 90 percent of known disease-causing genetic mutations. We envision a world where this technology can cure, halt, and ultimately prevent genetic diseases, providing lifelong benefit to patients. Prime Medicine offers the opportunity to shape the future of gene editing and transform how medicines are used to treat disease. Realizing the promise of Prime Editing requires a talented team with diversity of viewpoints and expertise. We’re building a group of dedicated, scientifically curious individuals who are passionate about helping patients live longer, healthier lives.